反应详情

Methylamine (4.2 g of a 33% solution in industrial methylated spirits) was added to a solution of the product of stage (a) (3 g) in methanol (60 ml) at room temperature. After standing for 23 days, the solution was run down under vacuum at less than 35° C. to give a brown oil. Trituration with a mixture of diethyl ether and isopropanol gave an off-white solid which was dried without heat to give 1.3 g of the desired product, mp 193°-198° C.

1. customwas run down under vacuum at less than 35° C.
2. customto give a brown oil
3. customgave an off-white solid which
4. customwas dried
5. temperaturewithout heat