Trifluoroacetic acid → HCID 19421452, compound

HRID 744025Notes

Reaction equation

HRID 744025 reaction equation
FC1C=CC(C(F)(F)F)=CC=1[N+]([O-])=O.COC1C=C(OC)C=CC=1CN.[CH2:27]([O:29][P:30]([CH2:35][C:36]1[N:40]2[C:41]3[C:46]([N:47](CC4C=CC(OC)=CC=4OC)[C:48](=[O:49])[C:39]2=[N:38][N:37]=1)=[CH:45][CH:44]=[C:43]([C:61]([F:64])([F:63])[F:62])[CH:42]=3)([O:32][CH2:33][CH3:34])=[O:31])[CH3:28].FC(F)(F)C(O)=O>>[CH2:33]([O:32][P:30]([CH2:35][C:36]1[N:40]2[C:41]3[C:46]([NH:47][C:48](=[O:49])[C:39]2=[N:38][N:37]=1)=[CH:45][CH:44]=[C:43]([C:61]([F:62])([F:64])[F:63])[CH:42]=3)([O:29][CH2:27][CH3:28])=[O:31])[CH3:34]

Participants

5

Reactant 4

HCID 6422Trifluoroacetic acidHCID 677784-Fluoro-3-nitrobenzotrifluorideHCID 5972502,4-DimethoxybenzylamineHCID 19421453HCID 19421453, compound

Product 1

HCID 19421452HCID 19421452, compound

Procedure

This compound was prepared by the procedure described in example 18 starting from 4-fluoro-3-nitrobenzotrifluoride and 2,4-dimethoxybenzylamine, except that the intermediate 1-[(diethoxyphosphoryl)methyl]-5-(2,4-dimethoxybenzyl)-8-trifluoromethyl[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one was deprotected by treatment with trifluoroacetic acid at room temperature overnight. The mixture was evaporated to dryness and the residue was recrystallized from ethanol to give the pure title compound, m.p. 204°-208° C.

Workup

  1. customThis compound was prepared by the procedure
  2. customThe mixture was evaporated to dryness
  3. customthe residue was recrystallized from ethanol

Sources & evidence

ORD record
ord-2dd7ed953a504d24a2f9e14880a9844f
Source dataset
uspto-grants-1996_09
Patent number
US05559106

Reaction notes

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