1-triphenylmethyl-4-[2-(4-trifluoromethylphenoxy)ethyl]-1H-imidazole → HCID 178506221, compound

HRID 744071Notes

Reaction equation

HRID 744071 reaction equation
C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)[N:8]2[CH:12]=[C:11]([CH2:13][CH2:14][O:15][C:16]3[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=3)[N:10]=[CH:9]2)C=CC=CC=1>O1CCCC1.Cl>[F:25][C:22]([F:23])([F:24])[C:19]1[CH:20]=[CH:21][C:16]([O:15][CH2:14][CH2:13][C:11]2[N:10]=[CH:9][NH:8][CH:12]=2)=[CH:17][CH:18]=1

Participants

4

Reactant 1

HCID 107439231-triphenylmethyl-4-[2-(4-trifluoromethylphenoxy)ethyl]-1H-imidazole

Product 1

HCID 178506221HCID 178506221, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of 640 mg (1.28 mmol) of 1-triphenylmethyl-4-[2-(4-trifluoromethylphenoxy)ethyl]-1H-imidazole in 2 ml of tetrahydrofuran and 5 ml of 2N hydrochloric acid is heated at 70° C. for 2 hours. The tetrahydrofuran is then evaporated under reduced pressure and the residue extracted with diethyl ether. The aqueous solution is basified with potassium carbonate and the white solid is filtered and washed 3 times with water to give the title compound, M.p.: 105°-109° C.

Workup

  1. customThe tetrahydrofuran is then evaporated under reduced pressure
  2. extractionthe residue extracted with diethyl ether
  3. filtrationthe white solid is filtered
  4. washwashed 3 times with water

Sources & evidence

ORD record
ord-4d7e20d1a9b84a3a95f3a22772ad9faa
Source dataset
uspto-grants-1996_09
Patent number
US05559113

Reaction notes

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