1-triphenylmethyl-4-[3-(4-fluorophenoxy)propyl]-1H-imidazole → HCID 178505893, compound

HRID 744080Notes

Reaction equation

HRID 744080 reaction equation
C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)[N:8]2[CH:12]=[C:11]([CH2:13][CH2:14][CH2:15][O:16][C:17]3[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=3)[N:10]=[CH:9]2)C=CC=CC=1>O1CCCC1.Cl>[F:23][C:20]1[CH:19]=[CH:18][C:17]([O:16][CH2:15][CH2:14][CH2:13][C:11]2[N:10]=[CH:9][NH:8][CH:12]=2)=[CH:22][CH:21]=1

Participants

4

Reactant 1

HCID 106001421-triphenylmethyl-4-[3-(4-fluorophenoxy)propyl]-1H-imidazole

Product 1

HCID 178505893HCID 178505893, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of 147 mg (0.4 mmol) of 1-triphenylmethyl-4-[3-(4-fluorophenoxy)propyl]-1H-imidazole in 1 ml of tetrahydrofuran and 2 ml of 2N hydrochloric acid is heated at 70° C. for 2 hours. The tetrahydrofuran is then evaporated under reduced pressure. The aqueous solution is filtered and basified with potassium bicarbonate. The product is extracted with chloroform and dried over magnesium sulphate. The solvent is evaporated under reduced pressure to give the title compound in the form of a white solid, M.p.: 135°-137° C.

Workup

  1. customThe tetrahydrofuran is then evaporated under reduced pressure
  2. filtrationThe aqueous solution is filtered
  3. extractionThe product is extracted with chloroform
  4. dry with materialdried over magnesium sulphate
  5. customThe solvent is evaporated under reduced pressure

Sources & evidence

ORD record
ord-e9a76f9c6b60485ab2c3eb96e25d83e9
Source dataset
uspto-grants-1996_09
Patent number
US05559113

Reaction notes

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