HCID 19696535, compound → 157023-27-3

HRID 744112Notes

Reaction equation

HRID 744112 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][CH2:15][CH2:16][CH:17]=[C:18](Br)Br)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Li]CCCC>C1COCC1>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][CH2:15][CH2:16][C:17]#[CH:18])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 19696535HCID 19696535, compoundHCID 178418339Butyllithium

Product 1

HCID 19696540157023-27-3

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 1-3 (1.70 g, 4.13 mmol) in THF (80 ml) was cooled to -78° and treated with n-BuLi (4.25 mmol) with stirring for 15 min. The reaction was then quenched with 10% KHSO4 (25 ml) and the solvent was removed. The residue was taken up in Et2O (150 ml) and this was washed with 10% KHSO4 solution, brine, and dried (Na2SO4).

Workup

  1. customThe reaction was then quenched with 10% KHSO4 (25 ml)
  2. customthe solvent was removed
  3. washthis was washed with 10% KHSO4 solution, brine
  4. dry with materialdried (Na2SO4)

Sources & evidence

ORD record
ord-f2ae03733c6f40babc9092991e3a61ce
Source dataset
uspto-grants-1996_09
Patent number
US05559127

Reaction notes

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