Sodium hydride → HCID 67770761, compound

HRID 744132Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([N:12]([C@@H:20]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH2:21][N:22]2[CH2:26][CH2:25][CH2:24][CH2:23]2)[CH2:13][CH2:14][C:15]([O:17]CC)=O)=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8].[H-].[Na+]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[C:15](=[O:17])[CH2:14][CH2:13][N:12]([C@@H:20]([C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)[CH2:21][N:22]3[CH2:26][CH2:25][CH2:24][CH2:23]3)[C:10]2=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

Reactant 2

HCID 24758Sodium hydride

HCID 54134198HCID 54134198, compound

Product 1

HCID 67770761HCID 67770761, compoundYield 95.7%

Procedure

The operation is carried out as in Example 2 starting with 28.6 g of the product obtained in Example 11, using 3.3 g sodium hydride. 24.74 g of desired product is obtained which is used as it is for the following example. M.p.=110°-115° C. crystallized from diethyl ether.

Sources & evidence

ORD record: ord-a1dad9e03bce443daa18a7c5bd59ed08
Source dataset: uspto-grants-1996_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05559130

Reaction notes

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