Isopropanol → HCID 19016549, compound

HRID 744599Notes

Reaction equation

HRID 744599 reaction equation
[Na].Cl[C:3]1[C:4]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)=[N:5][S:6][N:7]=1.[CH:14]([OH:17])([CH3:16])[CH3:15]>>[CH:14]([O:17][C:3]1[C:4]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)=[N:5][S:6][N:7]=1)([CH3:16])[CH3:15]

Participants

4

Reactant 3

HCID 3776IsopropanolHCID 5360545SodiumHCID 104881643-Chloro-4-(pyridin-3-yl)-1,2,5-thiadiazole

Product 1

HCID 19016549HCID 19016549, compoundYield 98%

Conditions

Temperature
25 °C

Procedure

To a solution of sodium (290 mg, 12.5 mmol) in isopropanol (10 ml) was added 3-(4-chloro-1,2,5-thiadiazol-3-yl)pyridine (490 mg, 2.5 mmol). The mixture was stirred at 25° C. for 18 h and evaporated. The residue was dissolved in water and extracted with ethyl acetate. The combined organic phases were dried and evaporated to yield 540 mg (98%) of the title compound.

Workup

  1. customevaporated
  2. dissolutionThe residue was dissolved in water
  3. extractionextracted with ethyl acetate
  4. customThe combined organic phases were dried
  5. customevaporated

Sources & evidence

ORD record
ord-d79efd7795b14f3fafe3a6fcbe0e5a75
Source dataset
uspto-grants-1996_09
Patent number
US05559138

Reaction notes

Loading…