Diethylene Glycol Monomethyl Ether → HCID 19075261, compound

HRID 744645Notes

Reaction equation

HRID 744645 reaction equation
[Na].Cl[C:3]1[C:4]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)=[N:5][S:6][N:7]=1.[CH3:14][O:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][OH:21]>>[CH3:14][O:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][O:21][C:3]1[C:4]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)=[N:5][S:6][N:7]=1

Participants

4

Reactant 3

HCID 8134Diethylene Glycol Monomethyl EtherHCID 5360545SodiumHCID 104881643-Chloro-4-(pyridin-3-yl)-1,2,5-thiadiazole

Product 1

HCID 19075261HCID 19075261, compound

Conditions

Temperature
50 °C

Procedure

To a solution of sodium (210 mg, 9 mmol) in 2-(2-methoxyethoxy)ethanol (10 ml) was added 3-(4-chloro-1,2,5-thiadiazol-3-yl)pyridine (590 mg, 3 mmol). The mixture was stirred at 50° C. for 4 h and evaporated. The residue was dissolved in water and extracted with ether. The combined organic phases were dried and evaporated to give the title compound.

Workup

  1. customevaporated
  2. dissolutionThe residue was dissolved in water
  3. extractionextracted with ether
  4. customThe combined organic phases were dried
  5. customevaporated

Sources & evidence

ORD record
ord-88b082b864ff48b58b9d07b8bbe3091d
Source dataset
uspto-grants-1996_09
Patent number
US05559138

Reaction notes

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