反应详情

温度

100 °C

22.6 g (139 mmol) 1,1′-carbonyldiimidazole were added to a solution of 9.0 g (27.1 mmol) N3-(1-benzylpiperidin-4-yl)-quinoline-3,4-diamine in 100 mL DMF. The mixture was heated to 100° C. and stirred for 1.5 h at this temperature. After cooling the reaction mixture it was poured onto 300 mL water. The precipitated solid was filtered off, washed with water and dried at 30° C. i. vac. The residue was triturated with diethyl ether, suction filtered and the solid product was dried i. vac.

1. temperatureAfter cooling the reaction mixture it
2. filtrationThe precipitated solid was filtered off
3. washwashed with water
4. customdried at 30° C. i
5. customThe residue was triturated with diethyl ether, suction
6. filtrationfiltered
7. customthe solid product was dried i