Methanol → HCID 49823212, compound

HRID 745123Notes

Reaction equation

HRID 745123 reaction equation
[CH3:1][C:2]([CH3:46])([O:4][C:5]([NH:7][CH:8]([CH2:39][C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1)[CH:9]([OH:38])[CH2:10][N:11](CC1C=CC=CC=1)[CH2:12][CH:13]([OH:30])[CH:14]([NH:22][C:23](=[O:29])[O:24][C:25]([CH3:28])([CH3:27])[CH3:26])[CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:6])[CH3:3].CO>CN(C=O)C>[CH3:28][C:25]([O:24][C:23](=[O:29])[NH:22][CH:14]([CH2:15][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)[CH:13]([OH:30])[CH2:12][NH:11][CH2:10][CH:9]([OH:38])[CH:8]([NH:7][C:5]([O:4][C:2]([CH3:1])([CH3:3])[CH3:46])=[O:6])[CH2:39][C:40]1[CH:41]=[CH:42][CH:43]=[CH:44][CH:45]=1)([CH3:26])[CH3:27]

Participants

4

Reactant 2

HCID 887MethanolHCID 6915783HCID 6915783, compound

Product 1

HCID 49823212HCID 49823212, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of Compounds 26a(i) and 26a(ii) were reacted with Compound 27a by a procedure analogous to that used for the preparation of Compound 4b (except that MeOH at 55° was used in place of DMF) to give the title Compound 27b as a mixture of diastereomers. m.p. 156°-159° C.; MS: (CI/NH3): 544 (M+H). Anal. Calc. for C30H45N3O6 ·0.16 H2O

Sources & evidence

ORD record
ord-1b6fddeb79724d34af69831bd4620a47
Source dataset
uspto-grants-1996_09
Patent number
US05559256

Reaction notes

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