反应详情

3.50 g (17.2 mmol) 1-acetyl-3,3-dimethyl-1,3-dihydro-indol-2-one were refluxed in 50 mL of a 6N hydrochloric acid solution for 1h. After cooling the reaction mixture was divided between tert-butylmethylether and water. The organic phase was washed with water, dried and evaporated down. The residue was crystallised from PE. The solid was suction filtered and dried at 80° C. in the CAD.

1. temperatureAfter cooling the reaction mixture
2. washThe organic phase was washed with water
3. customdried
4. customevaporated down
5. customThe residue was crystallised from PE
6. filtrationfiltered
7. customdried at 80° C. in the CAD