Hydrochloric Acid → 2-methyl-1-(3-methylphenyl)propan-2-amine

HRID 74525Notes

Reaction equation

HRID 74525 reaction equation
[CH3:1][C:2]([NH:12]C=O)([CH3:11])[CH2:3][C:4]1[CH:5]=[C:6]([CH3:10])[CH:7]=[CH:8][CH:9]=1.Cl.C(=O)([O-])[O-].[K+].[K+]>O>[CH3:11][C:2]([NH2:12])([CH3:1])[CH2:3][C:4]1[CH:5]=[C:6]([CH3:10])[CH:7]=[CH:8][CH:9]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 58386543HCID 58386543, compound

Product 1

HCID 1164832-methyl-1-(3-methylphenyl)propan-2-amine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1.80 g (9.41 mmol) N-(1,1-dimethyl-2-m-tolylethyl)-formamide, 20 mL water and 20 mL conc. hydrochloric acid were refluxed for 2 h. The reaction mixture was diluted with 20 mL ice water and made alkaline with saturated potassium carbonate solution. The aqueous phase was extracted with DCM (2×20 mL). The organic phase was washed with water, dried on sodium sulphate and evaporated down i. vac. The residue was co-evaporated with toluene (2×).

Workup

  1. extractionThe aqueous phase was extracted with DCM (2×20 mL)
  2. washThe organic phase was washed with water
  3. customdried on sodium sulphate
  4. customevaporated down i

Sources & evidence

ORD record
ord-5b6a6b5afe864e2491b5054a0226c6a5
Source dataset
uspto-grants-2014_09
Patent number
US08829006B2

Reaction notes

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