反应详情

To a stirred mixture of 22 parts of methyl 2,4-dichlorobenzeneacetate and 135 parts of N,N-dimethylformamide are added 3.1 parts of sodium hydride dispersion 78% while nitrogen gas is introduced. The whole is stirred till foaming has ceased and cooled in an ice-bath. Then there are added dropwise 16 parts of iodomethane. Upon completion, stirring is continued for 3 hours at room temperature. The reaction mixture is poured onto water and the product is extracted with 2,2'-oxybispropane. The extract is washed with water, dried, filtered and evaporated, yielding 20 parts (80%) of methyl 2,4-dichloro-α-methylbenzeneacetate as a residue.

1. additionis introduced
2. temperaturecooled in an ice-bath
3. stirringUpon completion, stirring
4. additionThe reaction mixture is poured onto water
5. extractionthe product is extracted with 2,2'-oxybispropane
6. washThe extract is washed with water
7. customdried
8. filtrationfiltered
9. customevaporated