Hydrochloric Acid → HCID 13288294, compound

HRID 745510Notes

Reaction equation

HRID 745510 reaction equation
[CH3:1][C:2]1[CH:31]=[CH:30][CH:29]=[CH:28][C:3]=1[O:4][CH2:5][CH:6]([OH:27])[CH2:7][NH:8][C:9]([CH3:26])([CH3:25])[CH2:10][NH:11][C:12]1[N:17]=[N:16][C:15]([NH:18][NH:19]C(OCC)=O)=[CH:14][CH:13]=1.[ClH:32]>>[ClH:32].[CH3:1][C:2]1[CH:31]=[CH:30][CH:29]=[CH:28][C:3]=1[O:4][CH2:5][CH:6]([OH:27])[CH2:7][NH:8][C:9]([CH3:26])([CH3:25])[CH2:10][NH:11][C:12]1[N:17]=[N:16][C:15]([NH:18][NH2:19])=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 23313328HCID 23313328, compound

Product 1

HCID 13288294HCID 13288294, compound

Procedure

A solution of 66 mg of 1-(2-methylphenoxy)-3-[1,1,-dimethyl-2-(3-ethoxycarbonylhydrazino-6-pyridazinylamino)ethylamino]-2-propanol in 5 ml of 10% hydrochloric acid was refluxed for 5 hours. After the solvent was evaporated under reduced pressure, the residue was recrystallized from ethanol to give 31 mg of 1-(2-methylphenoxy)-3-[1,1-dimethyl-2-(3-hydrazino-6-pyridazinylamino)ethylamino]-2-propanol hydrochloride as colorless crystals.

Workup

  1. customAfter the solvent was evaporated under reduced pressure
  2. customthe residue was recrystallized from ethanol

Sources & evidence

ORD record
ord-863b605c03e043e99bc7aab447232f32
Source dataset
uspto-grants-1986_07
Patent number
US04599333

Reaction notes

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