反应详情

温度

-78 °C

Under an argon atmosphere 5.0 g (25 mmol) 2-chloro-6-methoxyquinoline in a small amount of THF were added dropwise at −78° C. to 14 mL (28 mmol) of a 2 M lithium diisopropylamide solution (in THF) in 50 mL THF. Then the mixture was stirred for 1.5 h at −78° C. and 4.5 mL (25 mmol) N-benzylpiperidone was added dropwise. The mixture was stirred for a further 15 min with cooling before slowly being heated to RT. The reaction mixture was stirred overnight, evaporated down and purified by flash chromatography on aluminium oxide. The product-containing fractions were combined and evaporated down.

1. stirringThe mixture was stirred for a further 15 min
2. temperaturewith cooling
3. temperaturebefore slowly being heated to RT
4. stirringThe reaction mixture was stirred overnight
5. customevaporated down
6. custompurified by flash chromatography on aluminium oxide
7. customevaporated down