Sodium Bicarbonate → 2-(2-Aminoethoxyimino)-2-(2-formamidothiazol-4-yl)acetic acid

HRID 745707Notes

Reaction equation

HRID 745707 reaction equation
[CH:1]([NH:3][C:4]1[S:5][CH:6]=[C:7]([C:9](=O)[C:10]([OH:12])=[O:11])[N:8]=1)=[O:2].Cl.Cl.[NH2:16][O:17][CH2:18][CH2:19][NH2:20].C(=O)(O)[O-].[Na+]>C(O)C.O>[NH2:20][CH2:19][CH2:18][O:17][N:16]=[C:9]([C:7]1[N:8]=[C:4]([NH:3][CH:1]=[O:2])[S:5][CH:6]=1)[C:10]([OH:12])=[O:11]

Participants

6

Reactant 3

HCID 516892Sodium BicarbonateHCID 13116693(2-Formamido-1,3-thiazol-4-yl)(oxo)acetic acidHCID 143623262-(O-aminooxy)ethylamine dihydrochloride

Product 1

HCID 543766712-(2-Aminoethoxyimino)-2-(2-formamidothiazol-4-yl)acetic acid

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

To a solution of 2-(2-formamidothiazol-4-yl)glyoxylic acid (5.5 g.) in ethanol (100 ml. ) was added a solution of 2-(aminooxy)ethylamine.dihydrochloride (4.1 g.) in water (50 ml.). The resulting mixture was adjusted to pH 4 with an aqueous solution of sodium bicarbonate and stirred for 3 hours at room temperature.

Sources & evidence

ORD record
ord-9f3a6031062b4a48ada09d11faefac1b
Source dataset
uspto-grants-1986_07
Patent number
US04599426

Reaction notes

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