Hydrochloric Acid → HCID 23312160, compound

HRID 745769Notes

Reaction equation

HRID 745769 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[N:7]=[CH:8][C:9]2[NH:10][C:11]3[C:16]([C:17]=2[C:18]=1[CH2:19][CH3:20])=[CH:15][C:14]([C:21]([O:23]CC1C=CC=CC=1)=[O:22])=[CH:13][CH:12]=3)=[O:5])[CH3:2].Cl>CO.[Pd]>[CH2:1]([O:3][C:4]([C:6]1[N:7]=[CH:8][C:9]2[NH:10][C:11]3[C:16]([C:17]=2[C:18]=1[CH2:19][CH3:20])=[CH:15][C:14]([C:21]([OH:23])=[O:22])=[CH:13][CH:12]=3)=[O:5])[CH3:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 53896129HCID 53896129, compound

Product 1

HCID 23312160HCID 23312160, compoundYield 78.8%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

At room temperature and under normal pressure, 970 mg of 6-benzyloxycarbonyl-4-ethyl-β-carboline-3-carboxylic acid ethyl ester is hydrogenated for one hour in 50 ml of methanol with 3 ml of 1N hydrochloric acid and 1.50 g of 10% palladium/carbon. After the catalyst has been removed by filtration, the mixture is evaporated, thus obtaining 593 mg of 3-ethoxycarbonyl-4-ethyl-β-carboline-6-carboxylic acid as the hydrochloride.

Workup

  1. customAfter the catalyst has been removed by filtration
  2. customthe mixture is evaporated

Sources & evidence

ORD record
ord-f9045f39492e478ca998565551e45680
Source dataset
uspto-grants-1986_07
Patent number
US04600715

Reaction notes

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