Urea → HCID 53784406, compound

HRID 745960Notes

Reaction equation

HRID 745960 reaction equation
[CH3:1][O:2][C:3]([N:5]1[CH2:9][C:8]([N:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)=[C:7]([C:15](=[O:22])[CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH2:6]1)=[O:4].CO[CH:25](OC)[N:26]([CH3:28])[CH3:27].NC(N)=O>O1CCOCC1>[CH3:1][O:2][C:3]([N:5]1[CH2:9][C:8]([N:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)=[C:7]([C:15](=[O:22])[C:16]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:25][N:26]([CH3:28])[CH3:27])[CH2:6]1)=[O:4]

Participants

5

Reactant 3

HCID 1176UreaHCID 78373Dimethylformamide dimethyl acetalHCID 21270415HCID 21270415, compound

Product 1

HCID 53784406HCID 53784406, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of 12.41 g of N-methoxycarbonyl-3-carboethoxyacetyl-4-pyrrolidino-2,5-dihydropyrrole, 9.64 ml of N,N-dimethylformamide dimethylacetal and 10 mg of urea in 50 ml of dioxane is stirred under nitrogen for 16 hours. Evaporation of the solvent yields N-methoxycarbonyl-3-(2-ethoxycarbonyl-3-dimethylaminoacryloyl)-4-pyrrolidino-2,5-dihydropyrrole as an oil.

Workup

  1. customEvaporation of the solvent

Sources & evidence

ORD record
ord-666e64434d20470eab9e061891406faf
Source dataset
uspto-grants-1986_07
Patent number
US04602014

Reaction notes

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