Hydrochloric Acid → HCID 13656098, compound

HRID 745989Notes

Reaction equation

HRID 745989 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]3[CH:13]=[CH:14][C:15]([S:17]([CH2:20][C:21]([O-:23])=[O:22])(=[O:19])=[O:18])=[CH:16][C:11]=3[O:10][N:9]=2)=[CH:4][CH:3]=1.[OH-].[Na+].Cl>CO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]3[CH:13]=[CH:14][C:15]([S:17]([CH2:20][C:21]([OH:23])=[O:22])(=[O:19])=[O:18])=[CH:16][C:11]=3[O:10][N:9]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86740912HCID 86740912, compound

Product 1

HCID 13656098HCID 13656098, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3.1 g (8.17 mmol) of ethyl[[3-(4-chlorophenyl)-1,2-benzisoxazol-6-yl]sulfonylacetate was dissolved in 50 ml of methanol and an excess (15 ml) of 10% NaOH solution (15 ml) was added. The solution was refluxed for 15 minutes, cooled and acidified with 3N HCl. The white precipitate which formed was collected and recrystallized from 1:1 ethanol/water to give white crystals, 2.23 g (78%) of [[3-(4-chlorophenyl)-1,2-benzisoxazol-6-yl]sulfonyl]acetic acid, m.p. 201°-203° C.

Workup

  1. temperatureThe solution was refluxed for 15 minutes
  2. temperaturecooled
  3. customThe white precipitate which formed
  4. customwas collected
  5. customrecrystallized from 1:1 ethanol/water

Sources & evidence

ORD record
ord-955ca10cb9ca46f19586bbbc72a4f58f
Source dataset
uspto-grants-1986_07
Patent number
US04602028

Reaction notes

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