Hydrogen Bromide → HCID 178430867, compound

HRID 746088Notes

Reaction equation

HRID 746088 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]2[NH:11][CH:12]=[C:13]([CH3:15])[N:14]=2)=[CH:5][CH:4]=1.Br>C(O)(=O)C>[OH:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:9][C:10]2[NH:11][CH:12]=[C:13]([CH3:15])[N:14]=2)=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 178489885HCID 178489885, compound

Product 1

HCID 178430867HCID 178430867, compoundYield 90.7%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 2-(p-methoxyphenylmethyl)-4-methylimidazole (5.0 g, 0.025 m), glacial acetic acid (37 mL) and 48% hydrobromic acid (125 ml) was heated at reflux for 5 hours. The solution was concentrated under reduced pressure and the oily residue was stirred in saturated sodium bicarbonate solution (55 mL) for 17 hours. The solid was collected and dried to yield 4.22 g (90%) of II; m.p. 193°-194° C. (CH3CN).

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 5 hours
  3. concentrationThe solution was concentrated under reduced pressure
  4. customThe solid was collected
  5. customdried

Sources & evidence

ORD record
ord-7d37e4d88c884163ac4b5b53950c402a
Source dataset
uspto-grants-1986_07
Patent number
US04602093

Reaction notes

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