Potassium Carbonate → 3-[5'-bromo-2'-(5-fluoro-2,3-dihydro-indole-1-carbonyl)-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-4-yl]-7-methoxy-1,3,4,5-tetrahydro-benzo[d][1,3]-diazepin-2-one
Reaction equation
[Br:1][C:2]1[C:3](Cl)=[CH:4][C:5]([C:8]([N:10]2[C:18]3[C:13](=[CH:14][C:15]([F:19])=[CH:16][CH:17]=3)[CH2:12][CH2:11]2)=[O:9])=[N:6][CH:7]=1.[CH3:21][O:22][C:23]1[CH:24]=[CH:25][C:26]2[NH:32][C:31](=[O:33])[N:30]([CH:34]3[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]3)[CH2:29][CH2:28][C:27]=2[CH:40]=1.C(=O)([O-])[O-].[K+].[K+].CN1C(=O)CCC1>O>[Br:1][C:2]1[C:3]([N:37]2[CH2:36][CH2:35][CH:34]([N:30]3[CH2:29][CH2:28][C:27]4[CH:40]=[C:23]([O:22][CH3:21])[CH:24]=[CH:25][C:26]=4[NH:32][C:31]3=[O:33])[CH2:39][CH2:38]2)=[CH:4][C:5]([C:8]([N:10]2[C:18]3[C:13](=[CH:14][C:15]([F:19])=[CH:16][CH:17]=3)[CH2:12][CH2:11]2)=[O:9])=[N:6][CH:7]=1Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 130 °C
Procedure
0.38 g (1.1 mmol) (5-bromo-4-chloro-pyridin-2-yl)-(5-fluoro-2,3-dihydro-indol-1-yl)-methanone, 0.29 g (1.1 mmol) 7-methoxy-3-piperidin-4-yl-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one, 0.22 g (1.6 mmol) potassium carbonate and 3.0 mL NMP were combined and stirred for 10 h at 130° C. Then the reaction mixture was combined with water and the precipitate formed was suction filtered and dried.
Workup
- customthe precipitate formed
- filtrationfiltered
- customdried
Sources & evidence
- ORD record
- ord-a633e4fb3b634de089f2116385607dc7
- Source dataset
- uspto-grants-2014_09
- Patent number
- US08829006B2
Reaction notes
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