反应详情

100 mg (0.41 mmol) 3-piperidin-4-yl-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one were added to 110 mg (0.43 mmol) (2-chloropyridin-4-yl)-(2,3-dihydro-indol-1-yl)-methanone and 3.0 mL (17.4 mmol) DIPEA. The reaction mixture was refluxed for 5 h with stirring. Then 1 mL DMF were added and the mixture was stirred overnight at 130 C. After cooling water was added, the precipitate formed was suction filtered and purified by preparative HPLC. The product fractions were combined and evaporated down i. vac.

1. temperatureThe reaction mixture was refluxed for 5 h
2. stirringthe mixture was stirred overnight at 130 C
3. additionwas added
4. customthe precipitate formed
5. filtrationfiltered
6. custompurified by preparative HPLC
7. customevaporated down i