4-Piperidone → 4-Oxo-N-propylpiperidine-1-carboxamide

HRID 746205Notes

Reaction equation

HRID 746205 reaction equation
[NH:1]1[CH2:6][CH2:5][C:4](=[O:7])[CH2:3][CH2:2]1.[CH2:8]([N:11]=[C:12]=[O:13])[CH2:9][CH3:10]>>[CH2:8]([NH:11][C:12]([N:1]1[CH2:6][CH2:5][C:4](=[O:7])[CH2:3][CH2:2]1)=[O:13])[CH2:9][CH3:10]

Participants

3

Reactant 2

HCID 337214-PiperidoneHCID 61033Propyl isocyanate

Product 1

HCID 145711904-Oxo-N-propylpiperidine-1-carboxamide

Procedure

To piperid-4-one (11.8 g) was added n-propyl isocyanate in small portions at room temperature with stirring. After stirring 48 hr the solvent was removed in vacuo, and the residue was treated with diethyl ether, yielding (D.31) (19.1 g, 86%) as a pale yellow oil.

Workup

  1. stirringAfter stirring 48 hr the solvent
  2. customwas removed in vacuo
  3. additionthe residue was treated with diethyl ether
  4. customyielding (D.31) (19.1 g, 86%) as a pale yellow oil

Sources & evidence

ORD record
ord-c1ed351b0df2415d906d4fc835725c64
Source dataset
uspto-grants-1986_07
Patent number
US04603138

Reaction notes

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