反应详情

温度

130 °C

A mixture of o-nitrochlorobenzene (30 g) and 2-ethoxyethylamine (51 g) is stirred at 130° C. for 3 hours. After allowing to cool, ethyl acetate (150 ml) is added to the reaction mixture, and the ethyl acetate layer is separated, washed three times with saturated aqueous saline, dried over anhydrous magnesium sulfate, and then concentrated. The residue is distilled under reduced pressure to give N-(2-ethoxyethyl)-o-nitroaniline (42.9 g) as a reddish brown liquid, b.p. 144°-145.5° C./1.0 mmHg.

1. temperatureto cool
2. customthe ethyl acetate layer is separated
3. washwashed three times with saturated aqueous saline
4. dry with materialdried over anhydrous magnesium sulfate
5. concentrationconcentrated
6. distillationThe residue is distilled under reduced pressure