反应详情

100 mg (0.34 mmol) 1-piperidin-4-yl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one dihydrochloride and 200 μL (1.162 mmol) DIPEA were added to 100 mg (0.39 mmol) (6-chloropyrimidin-4-yl)-indol-1-yl-methanone in 30 mL DMF. The reaction mixture was stirred for 3 h at RT. The reaction mixture was evaporated down i. vac. The residue was combined with 20 mL water and stirred for 10 min. The solid was suction filtered and purified by flash chromatography. The product fractions were combined and evaporated down i. vac. The residue was triturated with diisopropylether and suction filtered. The solid was dried at 40° C. in the CAD.

1. customThe reaction mixture was evaporated down i
2. stirringstirred for 10 min
3. filtrationfiltered
4. custompurified by flash chromatography
5. customevaporated down i
6. customThe residue was triturated with diisopropylether and suction
7. filtrationfiltered
8. customThe solid was dried at 40° C. in the CAD