HRID74669

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8471

Triethylamine

C6H15N

结构：CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F

HCID2733207

O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate

C11H16BF4N5O

结构：O=C(O)c1cc(N2CCC(c3cc4ccccc4[nH]c3=O)CC2)ncn1

HCID58386504

未命名化合物

PRODUCTS

生成物

结构：O=C(c1cc(N2CCC(c3cc4ccccc4[nH]c3=O)CC2)ncn1)N1CCc2cc(F)ccc21

HCID58386721

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

Analogously to 3-{1-[6-(5-fluoro-2,3-dihydro-indole-1-carbonyl)-pyrimidin-4-yl]-piperidin-4-yl}-1H-quinolin-2-one the following compounds were prepared from in each case 0.23 mmol 6-[4-(2-oxo-1,2-dihydro-quinolin-3-yl)-piperidin-1-yl]-pyrimidine-4-carboxylic acid, 2.2 to 3.1 eq triethylamine, 1.2 eq TBTU and 1.1 equivalents of the respective amine in 3 mL DMF:

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3730087a55544cbeb6572c94ce88e050
来源数据集: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08829006B2
来源说明: uspto-grants-2014_09

反应 SMILES

[O:1]=[C:2]1[C:11]([CH:12]2[CH2:17][CH2:16][N:15]([C:18]3[N:23]=[CH:22][N:21]=[C:20]([C:24](O)=[O:25])[CH:19]=3)[CH2:14][CH2:13]2)=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[NH:3]1.C([N:29]([CH2:32][CH3:33])[CH2:30][CH3:31])C.CN(C(ON1N=N[C:44]2[CH:45]=[CH:46]C=C[C:43]1=2)=[N+](C)C)C.[B-](F)(F)(F)[F:52]>CN(C=O)C>[F:52][C:44]1[CH:45]=[C:46]2[C:30](=[CH:31][CH:43]=1)[N:29]([C:24]([C:20]1[N:21]=[CH:22][N:23]=[C:18]([N:15]3[CH2:16][CH2:17][CH:12]([C:11]4[C:2](=[O:1])[NH:3][C:4]5[C:9]([CH:10]=4)=[CH:8][CH:7]=[CH:6][CH:5]=5)[CH2:13][CH2:14]3)[CH:19]=1)=[O:25])[CH2:32][CH2:33]2