反应详情

温度

100 °C

Mix 5-amino-2-bromobenzonitrile (0.76 mmol) in anhydrous THF (3 ml), N,N-diisopropylethylamine (0.92 mmol), and bromoacetonitrile (1.0 mmol) at room temperature under inert atmosphere. Heat the mixture to 100° C. for 16 h in a sealed tube. Cool in ice bath, filter the precipitate and evaporate the filtrate to dryness to afford a crude residue. Purify by flash chromatography (Silica gel-CHCl3/Ethanol/NH4OH 9:1:0.1) to yield the title compound.

1. temperatureCool in ice bath
2. filtrationfilter the precipitate
3. customevaporate the filtrate to dryness
4. customto afford a crude residue
5. customPurify by flash chromatography (Silica gel-CHCl3/Ethanol/NH4OH 9:1:0.1)