Hydrochloric Acid → HCID 69254967, compound

HRID 746788Notes

Reaction equation

HRID 746788 reaction equation
[OH-].[Na+].C([O:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[S:21][CH:22]=[CH:23][C:24]=3[NH:25][S:26]([CH:29]([CH3:31])[CH3:30])(=[O:28])=[O:27])=[CH:16][CH:15]=2)=[CH:10][CH:9]=1)=[O:7])C.Cl>C(O)C>[CH3:31][CH:29]([S:26]([NH:25][C:24]1[CH:23]=[CH:22][S:21][C:20]=1[C:17]1[CH:18]=[CH:19][C:14]([C:11]2[CH:12]=[CH:13][C:8]([C:6]([OH:7])=[O:5])=[CH:9][CH:10]=2)=[CH:15][CH:16]=1)(=[O:27])=[O:28])[CH3:30]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 58900184HCID 58900184, compound

Product 1

HCID 69254967HCID 69254967, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Add NaOH 2M (1 ml) to a suspension of 4′-[3-(propane-2-sulfonylamino)-thiophen-2-yl]-biphenyl-4-carboxylic acid ethyl ester (0.128 mmol) in ethanol (1 ml) and stir 24 h. Add 6N HCl until pH is approximately 1 and a white solid precipitates. Filter the solid to provide the title compound: MS (ES−): 400 (M−1).

Workup

  1. customa white solid precipitates
  2. filtrationFilter the solid

Sources & evidence

ORD record
ord-1f3b66bcfecb44029c68dce927aa8754
Source dataset
uspto-grants-2008_07
Patent number
US07393868B2

Reaction notes

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