HRID74680

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

HCID18356852

未命名化合物

HCID58386674

未命名化合物

PRODUCTS

生成物

结构：COc1ccc2c(c1)CCN(C1CCN(c3cc(C(=O)N4CCc5cc(F)ccc54)ncc3C#N)CC1)C(=O)N2

HCID42612980

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

2 次

PROCEDURE

实验过程

150 mg (0.50 mmol) 4-chloro-6-(5-fluoro-2,3-dihydro-indole-1-carbonyl)-nicotinonitrile, 137 mg (0.50 mmol) 7-methoxy-3-piperidin-4-yl-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one and 103 mg (0.75 mmol) potassium carbonate in 2 mL DMF were stirred for 10 h at 130° C. Then the reaction mixture was diluted with 4 mL DMF and the precipitate formed was suction filtered. The filtrate was purified by preparative HPLC-MS. The product-containing fractions were combined and freeze-dried.

WORKUP

后处理

customthe precipitate formed
filtrationfiltered
customThe filtrate was purified by preparative HPLC-MS
customfreeze-dried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e2e600f1fb8c4cb1a42d0b186292d287
来源数据集: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08829006B2
来源说明: uspto-grants-2014_09

反应 SMILES

Cl[C:2]1[C:7]([C:8]#[N:9])=[CH:6][N:5]=[C:4]([C:10]([N:12]2[C:20]3[C:15](=[CH:16][C:17]([F:21])=[CH:18][CH:19]=3)[CH2:14][CH2:13]2)=[O:11])[CH:3]=1.[CH3:22][O:23][C:24]1[CH:25]=[CH:26][C:27]2[NH:33][C:32](=[O:34])[N:31]([CH:35]3[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]3)[CH2:30][CH2:29][C:28]=2[CH:41]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[F:21][C:17]1[CH:16]=[C:15]2[C:20](=[CH:19][CH:18]=1)[N:12]([C:10]([C:4]1[N:5]=[CH:6][C:7]([C:8]#[N:9])=[C:2]([N:38]3[CH2:37][CH2:36][CH:35]([N:31]4[CH2:30][CH2:29][C:28]5[CH:41]=[C:24]([O:23][CH3:22])[CH:25]=[CH:26][C:27]=5[NH:33][C:32]4=[O:34])[CH2:40][CH2:39]3)[CH:3]=1)=[O:11])[CH2:13][CH2:14]2