Hydrochloric Acid → Cinacalcet Hydrochloride

HRID 746839Notes

Reaction equation

HRID 746839 reaction equation
[CH3:1][C@@H:2]([NH:13][CH2:14][CH2:15][CH2:16][C:17]1[CH:18]=[CH:19][CH:20]=[C:21]([C:23]([F:26])([F:25])[F:24])[CH:22]=1)[C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=12.[ClH:27]>CC(OC)(C)C>[CH3:1][C@@H:2]([NH:13][CH2:14][CH2:15][CH2:16][C:17]1[CH:18]=[CH:19][CH:20]=[C:21]([C:23]([F:24])([F:25])[F:26])[CH:22]=1)[C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=12.[ClH:27]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 156419Cinacalcet

Product 1

HCID 156418Cinacalcet Hydrochloride

Reagents, catalysts & solvents 1

HCID 15413tert-Butyl methyl etherSolvent

Procedure

Cinacalcet base is dissolved in MTBE (20 volumes per gram of cinacalcet base). Then HCl gas (2 eq.) is bubbled into the solution at room temperature. The obtained slurry is stirred for 2 hours at room temperature. The product is isolated by filtration, washed with MTBE, and dried in a vacuum oven at 50° C. for 24 hours to obtain cinacalcet hydrochloride.

Workup

  1. customThe product is isolated by filtration
  2. washwashed with MTBE
  3. customdried in a vacuum oven at 50° C. for 24 hours

Sources & evidence

ORD record
ord-11ff5b02eb5d4453aded68ab72ecceb0
Source dataset
uspto-grants-2008_07
Patent number
US07393967B2

Reaction notes

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