Methanesulfonic Acid → HCID 86590261, compound

HRID 746918Notes

Reaction equation

HRID 746918 reaction equation
[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:24])=[C:11]([N:15]4[CH2:20][CH2:19][CH:18]([NH2:21])[C:17]([CH3:23])([CH3:22])[CH2:16]4)[C:12]=3[CH3:14])[C:7](=[O:25])[C:6]([C:26]([OH:28])=[O:27])=[CH:5]2)[CH2:3][CH2:2]1.[CH3:29][S:30]([OH:33])(=[O:32])=[O:31]>C(O)(C)C>[CH3:29][S:30]([OH:33])(=[O:32])=[O:31].[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:24])=[C:11]([N:15]4[CH2:20][CH2:19][CH:18]([NH2:21])[C:17]([CH3:22])([CH3:23])[CH2:16]4)[C:12]=3[CH3:14])[C:7](=[O:25])[C:6]([C:26]([OH:28])=[O:27])=[CH:5]2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 10221813HCID 10221813, compound

Product 1

HCID 86590261HCID 86590261, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Conditions

Temperature
75 °C

Procedure

The product obtained in example 68 (1 gm; 2.58 mmol) was suspended in 10 ml isopropyl alcohol. The reaction mixture was heated to 70 to 80° C. Methane sulfonic acid (0.25 g, 2.6 mmol) was added. The reaction mixture was cooled after 30 minutes f refluxing and was filtered at 10 to 20° C., dried under vacuum. Yield −0.76 gm (60%). C21H26FN3O3.CH4SO3, m/z 388 (M+1).

Workup

  1. temperatureThe reaction mixture was cooled after 30 minutes f
  2. temperaturerefluxing
  3. filtrationwas filtered at 10 to 20° C.
  4. customdried under vacuum

Sources & evidence

ORD record
ord-8001fa5d60804a798f25c0c8ab91197b
Source dataset
uspto-grants-2008_07
Patent number
US07393957B2

Reaction notes

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