Hydrochloric Acid → HCID 69205444, compound

HRID 747069Notes

Reaction equation

HRID 747069 reaction equation
C([O:4][CH:5]1[CH2:13][C:12]2[C:7](=[C:8]([NH:18]C(=O)C)[CH:9]=[CH:10][C:11]=2[NH:14]C(=O)C)[CH2:6]1)(=O)C.[ClH:22]>C(O)C>[ClH:22].[ClH:22].[NH2:14][C:11]1[CH:10]=[CH:9][C:8]([NH2:18])=[C:7]2[C:12]=1[CH2:13][CH:5]([OH:4])[CH2:6]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58794773HCID 58794773, compound

Product 1

HCID 69205444HCID 69205444, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.59 g of compound (5), 10 ml of ethanol and 10 ml of 37% hydrochloric acid were mixed in a three-necked flask. The reaction medium was refluxed. The reaction was followed by TLC. When the starting product and the monoacetylated product disappeared, the mixture was allowed to return to ambient temperature. The precipitate was then filtered off, washed with water and then with diisopropyl ether, and dried under vacuum. 944 mg of a white powder (yield=73%) were obtained.

Workup

  1. temperatureThe reaction medium was refluxed
  2. customto return to ambient temperature
  3. filtrationThe precipitate was then filtered off
  4. washwashed with water
  5. dry with materialwith diisopropyl ether, and dried under vacuum

Sources & evidence

ORD record
ord-26f4f11c66c341778427a38c9406ce28
Source dataset
uspto-grants-2008_07
Patent number
US07396369B2

Reaction notes

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