反应详情

A mixture of 3,4-difluoro-1,1′-biphenyl-4-ol (0.50 g, 2.43×10−3 mol) of 1-bromo-2-methoxyethane (0.34 g, 2.43×10−3 mol), potassium iodide (0.04 g, 2.43×10−4 mol), potassium carbonate (1.34 g, 9.72×10−3 mol) and butanone (20 cm3) was then heated overnight under reflux. The mixture was filtered to remove inorganic material and the filtrate evaporated down under reduced pressure. The crude product was purified by column chromatography on silica gel using dichloromethane as the eluent and recrystallisation from hexane to give the pure (GC: 100%) desired product (0.15 g 23%).

1. temperaturewas then heated overnight
2. temperatureunder reflux
3. filtrationThe mixture was filtered
4. customto remove inorganic material
5. customthe filtrate evaporated down under reduced pressure
6. customThe crude product was purified by column chromatography on silica gel
7. customas the eluent and recrystallisation from hexane