Potassium Iodide → HCID 69299641, compound

HRID 747076Notes

Reaction equation

HRID 747076 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)[CH:5]=[CH:6][C:7]=1[C:8]#[N:9].Br[CH2:18][CH2:19][O:20][CH3:21].[I-].[K+].C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[F:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH2:18][CH2:19][O:20][CH3:21])=[CH:12][CH:11]=2)[CH:5]=[CH:6][C:7]=1[C:8]#[N:9]

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 809722-Bromoethyl methyl etherHCID 15065645HCID 15065645, compound

Product 1

HCID 69299641HCID 69299641, compound

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

A mixture of 3-fluoro-4′-hydroxy-1,1′-biphenyl-4-carbonitrile (0.50 g, 2.35×10−3 mol), 1-bromo-2-methoxyethane (0.33 g, 2.35×10−3 mol), potassium iodide (0.04 g, 2.35×10−4 mol) and potassium carbonate (1.30 g, 9.40×10−3 mol) in butanone (20 cm3) was reacted, worked up and purified as described for compound 3 in Example 2. Yield 0.40 g (63%), GC purity (99.86%).

Workup

  1. customwas reacted
  2. custompurified

Sources & evidence

ORD record
ord-e40f0fd3fe574bbbbf7bf2ba072ebddc
Source dataset
uspto-grants-2008_07
Patent number
US07396487B2

Reaction notes

Loading…