Hydrochloric Acid → HCID 86611689, compound

HRID 747093Notes

Reaction equation

HRID 747093 reaction equation
[NH:1]([CH:4]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[N:5]1[CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7][CH2:6]1)[C:2]#[N:3].[ClH:24]>O1CCOCC1>[ClH:24].[C:18]1([C:4](=[N:1][C:2]#[N:3])[N:5]2[CH2:6][CH2:7][NH:8][CH2:9][CH2:10]2)[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86611690HCID 86611690, compound

Product 1

HCID 86611689HCID 86611689, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

tert-Butyl 4-(cyanamido(phenyl)methyl)piperazine-1-carboxylate (1.5 g) was dissolved in 16 ml of 2M HCl in dioxane. After four hours, the solution was diluted with dioxane (20 ml) and the solid, (phenyl(piperazin-1-yl)methylene)cyanamide hydrochloride (1 g), was collected via filtration. It was washed with ether before further use.

Workup

  1. filtrationthe solid, (phenyl(piperazin-1-yl)methylene)cyanamide hydrochloride (1 g), was collected via filtration
  2. washIt was washed with ether before further use

Sources & evidence

ORD record
ord-9b98787018c34b8493358f967ea80a46
Source dataset
uspto-grants-2008_07
Patent number
US07396830B2

Reaction notes

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