Formaldehyde → [6-(1-Methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-pyrimidin-4-yl]-quinolin-7-yl-amine

HRID 747135Notes

Reaction equation

HRID 747135 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([NH:11][C:12]3[CH:17]=[C:16]([C:18]4[CH2:19][CH2:20][NH:21][CH2:22][CH:23]=4)[N:15]=[CH:14][N:13]=3)[CH:9]=2)[CH:4]=[CH:3][CH:2]=1.C=O.[C:26](O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+]>CC#N>[CH3:26][N:21]1[CH2:20][CH:19]=[C:18]([C:16]2[N:15]=[CH:14][N:13]=[C:12]([NH:11][C:8]3[CH:9]=[C:10]4[C:5]([CH:4]=[CH:3][CH:2]=[N:1]4)=[CH:6][CH:7]=3)[CH:17]=2)[CH2:23][CH2:22]1

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 5049666Sodium triacetoxyborohydrideHCID 22135542Quinolin-7-yl-[6-(1,2,3,6-tetrahydro-pyridin-4-yl)-pyrimidin-4-yl)-amine

Product 1

HCID 22135521[6-(1-Methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-pyrimidin-4-yl]-quinolin-7-yl-amine

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

This compound could be prepared from quinolin-7-yl-[6-(1,2,3,6-tetrahydro-pyridin-4-yl)-pyrimidin-4-yl]-amine and formaldehyde in the presence of sodium triacetoxyborohydride and MeCN.

Sources & evidence

ORD record
ord-b169793700154b17a3bae14ec892bd41
Source dataset
uspto-grants-2008_07
Patent number
US07396831B2

Reaction notes

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