反应详情

温度

100 °C

N,N-Dimethylformamide dimethyl acetal (5 ml) was added to 1-(2-furyl)-2-(4-pyridyl)-1-ethanone (2.0 g, 10.7 mmol) and the mixture was stirred at 100° C. for 2 hours. After cooling as it was, the reaction mixture was diluted with ethyl acetate and a saturated aqueous ammonium chloride solution. The aqueous layer was extracted with ethyl acetate (×6). The combined organic layers were dried over anhydrous sodium sulfate and then concentrated, to give the title compound (2.5 g, 97%) as a reddish brown oil.

1. temperatureAfter cooling as it
2. extractionThe aqueous layer was extracted with ethyl acetate (×6)
3. dry with materialThe combined organic layers were dried over anhydrous sodium sulfate
4. concentrationconcentrated