反应详情

温度

0 °C

[3-(4-Bromo-phenyl)-4,5-dihydro-isoxazol-5-yl]-methanol (84.3 g, 328 mmol) was added to anhydrous dichloromethane (500 ml) followed by addition of triethylamine (64.1 ml, 459.2 mmol). The solution was allowed to cool to 0° C. followed by dropwise addition of methane sulfonyl chloride (30.65 ml, 396 mmol). The reaction was stirred for 2 hours at 0° C. and then aqueous sodium bicarbonate (200 ml) was added. After further extraction with dichloromethane (2×200 ml), the organic layers were combined, dried over sodium sulfate, and concentrated in vacuo to give the desired product (110 g).

1. extractionAfter further extraction with dichloromethane (2×200 ml)
2. dry with materialdried over sodium sulfate
3. concentrationconcentrated in vacuo