反应详情

温度

100 °C

5-Azidomethyl-3-(4-bromo-phenyl)-4,5-dihydro-isoxazol (12.3 g, 43.6 mmol) and bicyclo[2.2.1]hepta-2,5-diene (23.6 ml, 218.1 mmol) were added to dioxane (200 ml), heated to 100° C. and stirred for six hours. The reaction mixture was concentrated in vacuo followed by addition of ethyl ether (200 ml). The precipitate was collected and washed with ethyl ether (3×20 ml) and dried under nitrogen to give the desired product (8.8 g).

1. concentrationThe reaction mixture was concentrated in vacuo
2. additionfollowed by addition of ethyl ether (200 ml)
3. customThe precipitate was collected
4. washwashed with ethyl ether (3×20 ml)
5. customdried under nitrogen