反应详情

温度

0 °C

[3-(5-Bromo-thien-2-yl)-4,5-dihydro-isoxazol-5-yl]-methylamine (2.1 g, 8 mmol) and triethylamine (1.7 ml, 12 mmol) were added to anhydrous dichloromethane (50 ml) and cooled to 0° C. Acetyl chloride (0.670 ml, 9.6 mmol) was then added dropwise and the reaction was stirred for 3 hours followed by addition of ethyl acetate (100 ml). The precipitate was collected and washed with water (2×25 ml) to give the desired product (1.2 g).

1. customThe precipitate was collected
2. washwashed with water (2×25 ml)