反应详情

[3-(5-Bromo-thien-2-yl)-4,5-dihydro-isoxazol-5-yl]-methylamine (2.2 g, 8.4 mmol) and diisopropylethylamine (7.3 ml, 42 mmol) were added to anhydrous methanol (50 ml) followed by addition of N′-[2,2-dichloro-1-methylethylidene]-4-methylbenzenesulfonohydrazide (3.2 g, 10.9 mmol). The reaction was stirred at room temperature for four hours and then ethyl acetate was added. The precipitate was collected and washed with water (2×25 ml) to give the desired product (793 mg).

1. customThe precipitate was collected
2. washwashed with water (2×25 ml)