Hydrochloric Acid → N-[3-(3-Aminopropyl)-4-[(benzyloxy)methyl]thiazol-2(3H)-ylidene]-4-(trifluoromethoxy)aniline

HRID 747509Notes

Reaction equation

HRID 747509 reaction equation
[CH2:1]([O:8][CH2:9][C:10]1[N:11]([CH2:27][CH2:28][CH2:29][NH:30]C(=O)OC(C)(C)C)[C:12](=[N:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][C:23]([F:26])([F:25])[F:24])=[CH:18][CH:17]=2)[S:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl>>[NH2:30][CH2:29][CH2:28][CH2:27][N:11]1[C:10]([CH2:9][O:8][CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)=[CH:14][S:13][C:12]1=[N:15][C:16]1[CH:17]=[CH:18][C:19]([O:22][C:23]([F:25])([F:26])[F:24])=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 22350977tert-Butyl 3-[4-[(benzyloxy)methyl]-2-{[4-(trifluoromethoxy)phenyl]-imino}thiazol-3(2H)-yl]propylcarbamate

Product 1

HCID 22350937N-[3-(3-Aminopropyl)-4-[(benzyloxy)methyl]thiazol-2(3H)-ylidene]-4-(trifluoromethoxy)aniline

Procedure

The compound (137 mg) obtained in the above (3) was treated in a similar manner to in Example 9 (2) to give the title compound (133 mg) as hydrochloride.

Sources & evidence

ORD record
ord-5ca2abec7a644b0cb4d53daa586ac9bc
Source dataset
uspto-grants-2008_07
Patent number
US07396842B2

Reaction notes

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