Hydrochloric Acid → N-[3-(3-Aminopropyl)-4-[(benzyloxy)methyl]thiazol-2(3H)-ylidene]-5-methoxy-2-pyridinamine

HRID 747511Notes

Reaction equation

HRID 747511 reaction equation
[OH:1][CH2:2][C:3]1[N:4]([CH2:17][CH2:18][CH2:19][NH:20]C(=O)OC(C)(C)C)[C:5](=[N:8][C:9]2[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][N:10]=2)[S:6][CH:7]=1.NCCCN1C(CO[CH2:39][C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)=CSC1=NC1C=CC(OC(F)(F)F)=CC=1.Cl>>[NH2:20][CH2:19][CH2:18][CH2:17][N:4]1[C:3]([CH2:2][O:1][CH2:39][C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)=[CH:7][S:6][C:5]1=[N:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][N:10]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 22350937N-[3-(3-Aminopropyl)-4-[(benzyloxy)methyl]thiazol-2(3H)-ylidene]-4-(trifluoromethoxy)anilineHCID 22351017tert-Butyl 3-[4-(hydroxymethyl)-2-[(5-methoxy-2-pyridyl)imino]-thiazol-3(2H)-yl]propylcarbamate

Product 1

HCID 22351036N-[3-(3-Aminopropyl)-4-[(benzyloxy)methyl]thiazol-2(3H)-ylidene]-5-methoxy-2-pyridinamine

Procedure

The compound (283 mg) obtained in the above (1) was treated in a similar manner to in Example 208 (3), (4) to give the title compound (128 mg) as hydrochloride.

Sources & evidence

ORD record
ord-ed1066877f764c78ac8aa7627af7b863
Source dataset
uspto-grants-2008_07
Patent number
US07396842B2

Reaction notes

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