Hydrochloric Acid → N-[3-(3-Aminopropyl)-4-{[(4-chlorobenzyl)(methyl)amino]methyl}-thiazol-2(3H)-ylidene]-4-(trifluoromethoxy)aniline

HRID 747513Notes

Reaction equation

HRID 747513 reaction equation
[Cl:1][C:2]1[CH:39]=[CH:38][C:5]([CH2:6][N:7]([CH2:9][C:10]2[N:11]([CH2:27][CH2:28][CH2:29][NH:30]C(=O)OC(C)(C)C)[C:12](=[N:15][C:16]3[CH:21]=[CH:20][C:19]([O:22][C:23]([F:26])([F:25])[F:24])=[CH:18][CH:17]=3)[S:13][CH:14]=2)[CH3:8])=[CH:4][CH:3]=1.Cl>>[NH2:30][CH2:29][CH2:28][CH2:27][N:11]1[C:10]([CH2:9][N:7]([CH2:6][C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:39][CH:38]=2)[CH3:8])=[CH:14][S:13][C:12]1=[N:15][C:16]1[CH:17]=[CH:18][C:19]([O:22][C:23]([F:24])([F:26])[F:25])=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 22350950tert-Butyl 3-[4-{[(4-chlorobenzyl)(methyl)amino]methyl}-2-{[4-(trifluoromethoxy)phenyl]imino}thiazol-3(2H)-yl]propylcarbamate

Product 1

HCID 23131537N-[3-(3-Aminopropyl)-4-{[(4-chlorobenzyl)(methyl)amino]methyl}-thiazol-2(3H)-ylidene]-4-(trifluoromethoxy)aniline

Procedure

The compound (80 mg) obtained in the above (1) was treated in a similar manner to in Example 9 (2) to give the title compound (83 mg) as hydrochloride.

Sources & evidence

ORD record
ord-7f2db7e260784f4b88b83b7b5b66469e
Source dataset
uspto-grants-2008_07
Patent number
US07396842B2

Reaction notes

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