Phenyl Isothiocyanate → HCID 22350954, compound

HRID 747532Notes

Reaction equation

HRID 747532 reaction equation
[NH2:1][CH2:2][CH2:3][NH:4][C:5](=[O:11])[O:6][C:7]([CH3:10])([CH3:9])[CH3:8].[C:12]1([N:18]=[C:19]=[S:20])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C(O)C>[NH:18]([C:19]([NH:1][CH2:2][CH2:3][NH:4][C:5](=[O:11])[O:6][C:7]([CH3:8])([CH3:10])[CH3:9])=[S:20])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

4

Reactant 2

HCID 7673Phenyl IsothiocyanateHCID 187201N-BOC-ethylenediamine

Product 1

HCID 22350954HCID 22350954, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
75 °C

Procedure

To a solution of t-butyl 2-aminoethylcarbamate (1.76 ml) in ethanol (22 ml) was added dropwise phenyl isothiocyanate (1.5 g), and the mixture was heated at 75° C. for one hour. The reaction mixture was concentrated under reduced pressure and crystallized from n-hexane to give the title compound (3.25 g).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customcrystallized from n-hexane

Sources & evidence

ORD record
ord-9b68812256f8419088589c9938ae7ec1
Source dataset
uspto-grants-2008_07
Patent number
US07396842B2

Reaction notes

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