反应详情

Under nitrogen, 1.0 g (3 mmol) of 3-[(2-methoxyethyl)amino]-2-methyl-4-(methylsulfonyl)benzoic acid was dissolved in 150 ml of THF, and 10 g of paraformaldehyde and then, a little at a time, 0.7 g (20 mmol) of NaBH4 were added. 15 ml of trifluoroacetic acid were then slowly added dropwise. The mixture was stirred at RT for another 3 days. For work-up, 10% strength H2SO4 was added, and the mixture was extracted repeatedly with EA and then dried over MgSO4 and concentrated. This gave a brownish oil.

1. extractionthe mixture was extracted repeatedly with EA
2. dry with materialdried over MgSO4
3. concentrationconcentrated
4. customThis gave a brownish oil