Sodium Hydroxide → 4-[N-[2-(3-cyanophenoxy)ethyl]carbamoyl]benzoic acid

HRID 747664ノート

反応式

HRID 747664 の反応式
[C:1]([C:3]1[CH:4]=[C:5]([CH:22]=[CH:23][CH:24]=1)[O:6][CH2:7][CH2:8][NH:9][C:10]([C:12]1[CH:21]=[CH:20][C:15]([C:16]([O:18]C)=[O:17])=[CH:14][CH:13]=1)=[O:11])#[N:2].[OH-].[Na+]>C(O)C.C1COCC1>[C:1]([C:3]1[CH:4]=[C:5]([CH:22]=[CH:23][CH:24]=1)[O:6][CH2:7][CH2:8][NH:9][C:10]([C:12]1[CH:13]=[CH:14][C:15]([C:16]([OH:18])=[O:17])=[CH:20][CH:21]=1)=[O:11])#[N:2]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 68830761methyl 4-[N-[2-(3-cyanophenoxy)ethyl)carbamoyl]benzoate

生成物 1

HCID 688315184-[N-[2-(3-cyanophenoxy)ethyl]carbamoyl]benzoic acid

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

310 mg (1 mmol) of methyl 4-[N-[2-(3-cyanophenoxy)ethyl]carbamoyl]benzoate was stirred in 15 ml of ethanol and 15 ml of THF. 3 ml of 1 N aqueous sodium hydroxide solution was added thereto and they were stirred at room temperature overnight. The reaction liquid was distilled under reduced pressure and then 1 N hydrochloric acid was added to the residue. After the extraction with ethyl acetate, the extract was washed with a saturated aqueous NaCl solution and then dried over anhydrous magnesium sulfate. The solvent was evaporated to obtain the title compound.

後処理

  1. customThe reaction liquid
  2. distillationwas distilled under reduced pressure
  3. addition1 N hydrochloric acid was added to the residue
  4. extractionAfter the extraction with ethyl acetate
  5. washthe extract was washed with a saturated aqueous NaCl solution
  6. dry with materialdried over anhydrous magnesium sulfate
  7. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-4255c8353a4c4dceb87a2d0a6959c9e6
出典データセット
uspto-grants-2008_07
特許番号
US07396844B1

反応ノート

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