Hydrochloric Acid → 1-(Pyridin-4-yl)piperidine-4-carboxylic acid hydrochloride

HRID 747680Notes

Reaction equation

HRID 747680 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:12][CH2:11][CH:10]([C:13]([O:15]CC)=[O:14])[CH2:9][CH2:8]2)=[CH:3][CH:2]=1.[ClH:18]>O1CCOCC1>[ClH:18].[N:1]1[CH:2]=[CH:3][C:4]([N:7]2[CH2:12][CH2:11][CH:10]([C:13]([OH:15])=[O:14])[CH2:9][CH2:8]2)=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 9899468Ethyl 1-(pyridin-4-yl)piperidine-4-carboxylate

Product 1

HCID 162172691-(Pyridin-4-yl)piperidine-4-carboxylic acid hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

2.95 g (12.6 mmol) of ethyl 1-(4-pyridyl)piperidine-4-carboxylate was stirred in 100 ml of dioxane. 50 ml of 1 N aqueous hydrochloric acid solution was added thereto, and the resultant mixture was stirred at 95° C. for 20 hours. The solvent was evaporated under reduced pressure to obtain the title compound.

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-f968195bc6e14ea7a4c15b2f96988c19
Source dataset
uspto-grants-2008_07
Patent number
US07396844B1

Reaction notes

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