Water → HCID 2228055, compound

HRID 747718Notes

Reaction equation

HRID 747718 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH2:7]Cl)([O-:3])=[O:2].[C:12]([C:14]1[CH:15]=[C:16]([OH:20])[CH:17]=[CH:18][CH:19]=1)#[N:13].C(=O)([O-])[O-].[K+].[K+].O>CN(C)C=O>[N+:1]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH2:7][O:20][C:16]1[CH:15]=[C:14]([CH:19]=[CH:18][CH:17]=1)[C:12]#[N:13])([O-:3])=[O:2]

Participants

6

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 12078alpha-Chloro-m-nitrotolueneHCID 133943-Cyanophenol

Product 1

HCID 2228055HCID 2228055, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1.70 g (10.0 mmol) of 3-nitrobenzyl chloride, 1.48 g (12.4 mmol) of 3-cyanophenol and 3.58 g (25.9 mmol) of potassium carbonate were suspended in 80 ml of dimethylformamide, and the resultant suspension was stirred at 95° C. overnight. After leaving the suspension to cool, 150 ml of water was added to the suspension, and the solid formed was taken by the filtration. The solid was washed with 100 ml of water and then 20 ml of ethyl acetate, and dried under reduced pressure to obtain the title compound.

Workup

  1. customAfter leaving the suspension
  2. temperatureto cool
  3. customthe solid formed
  4. filtrationwas taken by the filtration
  5. washThe solid was washed with 100 ml of water
  6. dry with material20 ml of ethyl acetate, and dried under reduced pressure

Sources & evidence

ORD record
ord-79fe735e99a045228d22edbdcae47973
Source dataset
uspto-grants-2008_07
Patent number
US07396844B1

Reaction notes

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