Hydrochloric Acid → Ethyl 4-(aminomethyl)benzoate

HRID 747740Notes

Reaction equation

HRID 747740 reaction equation
[NH2:1][CH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=1.Cl.[CH2:13](O)[CH3:14]>>[NH2:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([C:7]([O:9][CH2:13][CH3:14])=[O:8])=[CH:10][CH:11]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702Ethanol2×HCID 655264-(Aminomethyl)Benzoic Acid

Product 1

HCID 436161Ethyl 4-(aminomethyl)benzoate

Procedure

3 g (19.9 mmol) of 4-aminomethylbenzoic acid was suspended in 100 ml of ethanol. 10 ml of ethanol containing 25% of hydrogen chloride was added to the suspension, and they were heated under reflux for 8 hours. The solvent was evaporated, and the title compound was obtained by the same isolation process as that of step 1 in Example 1 with ethyl acetate as the extractant.

Workup

  1. temperaturewere heated
  2. temperatureunder reflux for 8 hours
  3. customThe solvent was evaporated

Sources & evidence

ORD record
ord-87b785d9a67d48c78c90f7eb6d0262e3
Source dataset
uspto-grants-2008_07
Patent number
US07396844B1

Reaction notes

Loading…